Interaction of macro- and microvascular function underlies brachial artery flow-mediated dilation in humans-Reference-Cited by-同舟云学术

Interaction of macro- and microvascular function underlies brachial artery flow-mediated dilation in humans

Published:2024-07-01 Issue:1 Volume:327 Page:H268-H274
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Thorn Clare E.¹²³^ORCID,Gates Phillip E.¹²,Casanova Francesco¹²,Ramalli Alessandro⁴,Tortoli Piero⁴^ORCID,Palombo Carlo⁵^ORCID,Shore Angela C.¹²,Aizawa Kunihiko¹²^ORCID

Affiliation:

1. Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, United Kingdom

2. National Institute of Health and Care Research Exeter Clinical Research Facility, Exeter, United Kingdom

3. Department of Health and Care Professions, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom

4. Department of Information Engineering, University of Florence, Florence, Italy

5. Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy

Abstract

Microvascular response to ischemia and subsequent reperfusion is diminished in older adults compared with the young. Furthermore, there appears to be a dissociation between the microvascular response to ischemia and brachial hyperemic WSR in older adults, which may further disturb the BAFMD process in this cohort. A reduced BAFMD in older adults may be a result of multiple alterations occurring both at macro- and microcirculation.

Funder

Innovative Medicine Initiatives

National Institute of Health and Care Research Exeter Clinical Research Facility

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00158.2024

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