Metabolic signatures of pregnancy-induced cardiac growth-Reference-Cited by-同舟云学术

Metabolic signatures of pregnancy-induced cardiac growth

Published:2022-07-01 Issue:1 Volume:323 Page:H146-H164
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Fulghum Kyle L.¹,Smith Juliette B.¹,Chariker Julia²,Garrett Lauren F.¹,Brittian Kenneth R.¹,Lorkiewicz Pawel K.¹^ORCID,McNally Lindsey A.¹,Uchida Shizuka³^ORCID,Jones Steven P.¹^ORCID,Hill Bradford G.¹,Collins Helen E.¹^ORCID

Affiliation:

1. Diabetes and Obesity Center, Christina Lee Brown Envirome Institute, Division of Environmental Medicine, Department of Medicine, University of Louisville, Louisville, Kentucky

2. Kentucky INBRE Genomics Core, University of Louisville, Louisville, Kentucky

3. Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, Copenhagen, Denmark

Abstract

Little is known of the underlying molecular and cellular mechanisms that contribute to pregnancy-induced cardiac growth. Several lines of evidence suggest that changes in cardiac metabolism may contribute. Here, we provide a comprehensive metabolic atlas of the metabolomic, proteomic, and transcriptomic changes occurring in the maternal heart. We show that pregnancy-induced cardiac growth is associated with changes in glycerophospholipid, nucleotide, and amino acid metabolism, with reductions in cardiac glucose catabolism. Collectively, these results suggest that substantial metabolic changes occur in the maternal heart during pregnancy and after pregnancy.

Funder

Jewish Heritage Fund for Excellence

University of Louisville School of Medicine

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | NIH Office of the Director

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00105.2022

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