Enhanced protein acetylation initiates fatty acid-mediated inhibition of cardiac glucose transport-Reference-Cited by-同舟云学术

Enhanced protein acetylation initiates fatty acid-mediated inhibition of cardiac glucose transport

Published:2023-03-01 Issue:3 Volume:324 Page:H305-H317
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

De Loof Marine¹,Renguet Edith¹,Ginion Audrey¹,Bouzin Caroline²^ORCID,Horman Sandrine¹,Beauloye Christophe¹³,Bertrand Luc¹⁴^ORCID,Bultot Laurent¹^ORCID

Affiliation:

1. Pole of Cardiovascular Research, Institute for Experimental and Clinical Research, UCLouvain, Brussels, Belgium

2. Institute for Experimental and Clinical Research, Imaging platform (2IP), UCLouvain, Brussels, Belgium

3. Division of Cardiology, Cliniques Universitaires Saint-Luc, Brussels, Belgium

4. WELBIO Department, WEL Research Institute, Wavre, Belgium

Abstract

Our results show that cardiac metabolic overload by oleate or palmitate leads to increased protein acetylation inhibiting GLUT4 translocation to the plasma membrane and glucose uptake. This observation suggests an additional regulation mechanism in the physiological glucose-FA cycle originally discovered by Randle.

Funder

Fonds National de la Recherche Scientifique

Federation Wallonia-Brussels

AstraZeneca

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00449.2022

Reference47 articles.

1. Cardiac metabolism as a driver and therapeutic target of myocardial infarction