Increased circulating microparticles contribute to severe infection and adverse outcomes of COVID-19 in patients with diabetes-Reference-Cited by-同舟云学术

Increased circulating microparticles contribute to severe infection and adverse outcomes of COVID-19 in patients with diabetes

Published:2022-12-01 Issue:6 Volume:323 Page:H1176-H1193
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Sun Haoyu¹^ORCID,Du Yong¹^ORCID,Kumar Rinki²,Buchkovich Nicholas²^ORCID,He Pingnian¹^ORCID

Affiliation:

1. Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania

2. Department of Microbiology and Immunology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania

Abstract

This study provides the first evidence that over 90% of human plasma microparticles express ACE2 that binds SARS-CoV-2 S protein with high affinity. Thus, the highly elevated adhesive circulating microparticles identified in patients with diabetes not only have greater SARS-CoV-2 binding capacity but also enable additional viral entry through virus-bound microparticle-endothelium interactions and enhanced infection. These findings reveal a novel mechanistic insight into the adverse outcomes of COVID-19 in patients with diabetes.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00409.2022

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