IL-33 supplementation improves uterine artery resistance and maternal hypertension in response to placental ischemia-Reference-Cited by-同舟云学术

IL-33 supplementation improves uterine artery resistance and maternal hypertension in response to placental ischemia

Published:2024-04-01 Issue:4 Volume:326 Page:H1006-H1016
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Wang Xi¹^ORCID,Shields Corbin¹,Tardo Geilda¹,Peacock Greg²,Hester Emily²,Anderson Marissa²,Williams Jan M.¹^ORCID,Cornelius Denise C.¹²^ORCID

Affiliation:

1. Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, United States

2. Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States

Abstract

Though decreased IL-33 signaling has been clinically associated with PE, the mechanisms linking this signaling pathway to overall disease pathophysiology are not well understood. This study provides compelling evidence that mechanistically links reduced IL-33 with the inflammatory response and vascular dysfunction observed in response to placental ischemia, such as in PE. Data presented in this study submit the IL-33 signaling pathway as a possible therapeutic target for the treatment of PE.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00045.2024

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