Author:
Heerman Jan R.,Segers Patrick,Roosens Carl D.,Gasthuys Frank,Verdonck Pascal R.,Poelaert Jan I.
Abstract
We studied whether combined pressure and transesophageal ultrasound monitoring is feasible in the intensive care unit (ICU) setting for global cardiovascular hemodynamic monitoring [systemic vascular resistance (SVR) and total arterial compliance (CPPM)] and direct estimation of local ascending and descending aortic mechanical properties, i.e., distensibility and compliance coefficients (DC and CC). Pressure-area data were fitted to the arctangent Langewouters model, with aortic cross-sectional area obtained via automated border detection. Data were measured in 19 subjects at baseline, during infusion of sodium nitroprusside (SNP), and after washout. SNP infusion lowered SVR from 1.15 ± 0.40 to 0.80 ± 0.32 mmHg·ml−1·s ( P < 0.05), whereas CPPM increased from 0.87 ± 0.46 to 1.02 ± 0.42 ml/mmHg ( P < 0.05). DC and CC increased from 0.0018 ± 0.0007 to 0.0025 ± 0.0009 l/mmHg ( P < 0.05) and from 0.0066 ± 0.0028 to 0.0083 ± 0.0026 cm2/mmHg ( P < 0.05), respectively, at the descending, but not ascending, aorta. The Langewouters model fitted the descending aorta data reasonably well. Assessment of local mechanical properties of the human ascending aorta in a clinical setting by automated border detection remains technically challenging.
Publisher
American Physiological Society
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology
Cited by
26 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献