Aerobic exercise training combined with local strength exercise restores muscle blood flow and maximal aerobic capacity in long-term Hodgkin lymphoma survivors

Author:

Santos Luciana De Souza1,Rehder Marília Harumi Higuchi dos Santos12,Negrao Marcelo Vailati3,Goes-Santos Beatriz R.4ORCID,Toshi Dias Edgar5ORCID,Paixão Camila Jordão1,Urias Ursula6,Giannetti Natali Schiavo1,Hajjar Ludhmila A.12ORCID,Filho Roberto Kalil1,Negrão Carlos E.16ORCID

Affiliation:

1. Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

2. Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

3. Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States

4. School of Physical Education, University of Campinas, Campinas, Brazil

5. Methodist University of São Paulo, São Paulo, Brazil

6. Escola de Educação Física e Esporte, Universidade de São Paulo, São Paulo, Brazil

Abstract

Long-term Hodgkin lymphoma (HL) survivors have impaired muscle blood flow responses during mental stress and decreased maximal aerobic capacity. Supervised aerobic exercise training combined with local strength exercises restores muscle blood flow responses during mental stress and maximal aerobic capacity in these survivors. These findings provide evidence of safety and effectiveness of exercise training in HL survivors. Moreover, they highlight the importance of exercise training in the treatment of this set of patients.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

American Physiological Society

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