Sex differences in the cardiac stress response following SARS-CoV-2 infection of ferrets-Reference-Cited by-同舟云学术

Sex differences in the cardiac stress response following SARS-CoV-2 infection of ferrets

Published:2023-11-01 Issue:5 Volume:325 Page:H1153-H1167
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Rouhana Sarah¹²,Jacyniak Kathy²,Francis Magen E.³,Falzarano Darryl³,Kelvin Alyson A.³,Pyle W. Glen¹²^ORCID

Affiliation:

1. IMPART Investigator Team, Dalhousie Medicine, Saint John, New Brunswick, Canada

2. Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada

3. Vaccine and Infectious Disease Organization-International Vaccine Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

Abstract

Cardiovascular disease is a leading risk factor for severe COVID-19, and cardiovascular pathologies are among the most common adverse outcomes following SARS-CoV-2 infection. Females and males have different outcomes and adverse cardiovascular events following SARS-CoV-2 infection. This study shows sex differences in stress proteins p62/SQSTM1, ERK1/2, and GSK3α/β, along with innate immunity and inflammation in hearts of ferrets infected with SARS-CoV-2, identifying mechanisms of COVID-19 cardiac injury and cardiac complications of long COVID.

Funder

Atlantic Genome/Genome Canada

Scotiabank COVID-19 IMPACT Grant

Nova Scotia COVID-19 Health Research Coalition

Gouvernement du Canada | Canadian Institutes of Health Research

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Heart and Stroke Foundation of Canada

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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