Enhanced endothelial barrier function by monoclonal antibody activation of vascular endothelial cadherin-Reference-Cited by-同舟云学术

Enhanced endothelial barrier function by monoclonal antibody activation of vascular endothelial cadherin

Published:2021-04-01 Issue:4 Volume:320 Page:H1403-H1410
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Park Ki-Sook¹²,Schecterson Leslayann²,Gumbiner Barry M.²³⁴

Affiliation:

1. Department of Biomedical Science and Technology/East-West Medical Research Institute, Kyung Hee University, Seoul, South Korea

2. Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute, Seattle, Washington

3. Department of Pediatrics, University of Washington, Seattle, Washington

4. Department of Biochemistry, University of Washington, Seattle, Washington

Abstract

Excessive vascular permeability is a serious complication of many inflammatory disease conditions. We have developed monoclonal antibodies that inhibit increases in endothelial monolayer permeability induced by several signaling factors by activating VE-cadherin mediated adhesion and stabilizing cell junctions. These antibodies and/or the mechanisms they reveal may lead to important therapeutics to treat vascular leakiness and inflammation.

Funder

HHS | NIH | National Cancer Institute

HHS | National Institutes of Health

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00002.2021

Reference32 articles.

1. Vascular Permeability and Drug Delivery in Cancers

2. The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications