Neuregulin-1 compensates for endothelial nitric oxide synthase deficiency-Reference-Cited by-同舟云学术

Neuregulin-1 compensates for endothelial nitric oxide synthase deficiency

Published:2021-06-01 Issue:6 Volume:320 Page:H2416-H2428
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Shakeri Hadis¹,Boen Jente R. A.¹²^ORCID,De Moudt Sofie¹,Hendrickx Jhana O.¹^ORCID,Leloup Arthur J. A.¹,Jacobs Griet¹^ORCID,De Meyer Guido R. Y.¹^ORCID,De Keulenaer Gilles W.¹³,Guns Pieter-Jan D. F.¹^ORCID,Segers Vincent F. M.¹⁴^ORCID

Affiliation:

1. Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium

2. Research Group Cardiovascular Diseases, GENCOR Department, University of Antwerp, Antwerp, Belgium

3. Hartcentrum ZNA, Antwerp, Belgium

4. Department of Cardiology, University Hospital Antwerp, Edegem, Belgium

Abstract

ECs compensate for eNOS deficiency by increasing the secretion of NRG1. NRG1 administration prevents cardiac and renal hypertrophy and fibrosis caused by ANG II infusion and eNOS deficiency. NRG1 expression is regulated by miR-134.

Funder

University of Antwerp

Fund for Scientific Research Flanders

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00914.2020

Reference71 articles.

1. Endothelium as an organ system

2. Molecular diversity of cardiac endothelial cells in vitro and in vivo