Deletion of cardiac polycystin 2/PC2 results in increased SR calcium release and blunted adrenergic reserve-Reference-Cited by-同舟云学术

Deletion of cardiac polycystin 2/PC2 results in increased SR calcium release and blunted adrenergic reserve

Published:2020-11-01 Issue:5 Volume:319 Page:H1021-H1035
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

DiNello Elisabeth¹²,Bovo Elisa¹²,Thuo Paula¹²,Martin Thomas G.³,Kirk Jonathan A.¹²^ORCID,Zima Aleksey V.¹²,Cao Quan¹²,Kuo Ivana Y.¹²⁴^ORCID

Affiliation:

1. Department of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois

2. Cardiovascular Research Institute, Loyola University Chicago, Chicago, Illinois

3. Graduate School, Loyola University Chicago, Chicago, Illinois

4. Department of Pharmacology, Yale University, New Haven, Connecticut

Abstract

Our goal was to characterize the role of the transient receptor potential channel polycystin 2 (PC2) in cardiomyocytes following adult-onset deletion. Loss of PC2 resulted in decreased cardiac shortening and cardiac dyssynchrony and diminished adrenergic reserve. These results suggest that cardiac-specific PC2 modulates intracellular calcium signaling and contributes to the maintenance of adrenergic pathways.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00302.2020

Reference48 articles.

1. Polycystin-1 Assembles With Kv Channels to Govern Cardiomyocyte Repolarization and Contractility

2. Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2