ATP induces contraction of cultured brain capillary pericytes via activation of P2Y-type purinergic receptors

Author:

Hørlyck Sofie1,Cai Changsi2,Helms Hans Christian Cederberg1,Lauritzen Martin23ORCID,Brodin Birger1ORCID

Affiliation:

1. Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

2. Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

3. Department of Clinical Neurophysiology, Rigshospitalet, Copenhagen, Denmark

Abstract

The study concerns brain capillary pericytes, which have been suggested to play a role in the regulation of cerebral blood flow. We show that extracellular ATP causes contraction of primary brain pericytes by stimulation of purinergic receptors and subsequent release of intracellular Ca2+ concentration ([Ca2+]i). The contraction is mainly mediated through activation of P2Y-receptor subtypes, including P2Y1 and P2Y2. These findings add more mechanistic understanding of the role of pericytes in regulation of capillary blood flow. ATP was earlier suggested to be involved in capillary constriction in brain pathologies, and our study gives a detailed account of a part of this important mechanism.

Funder

The Lundbeck Foundation

The Danish Medical Research Council

The Augustinus Foundation

The NOVO Nordisk Foundation

Nordea Foundation Grant

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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