Role of coronary flow regulation and cardiac-coronary coupling in mechanical dyssynchrony associated with right ventricular pacing-Reference-Cited by-同舟云学术

Role of coronary flow regulation and cardiac-coronary coupling in mechanical dyssynchrony associated with right ventricular pacing

Published:2021-03-01 Issue:3 Volume:320 Page:H1037-H1054
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Fan Lei¹,Namani Ravi¹^ORCID,Choy Jenny S.²,Awakeem Yousif²,Kassab Ghassan S.²,Lee Lik Chuan¹

Affiliation:

1. Department of Mechanical Engineering, Michigan State University, East Lansing, Michigan

2. California Medical Innovation Institute, San Diego, California

Abstract

A computational model that couples the systemic circulation of the left ventricular (LV) and coronary perfusion with flow regulation is developed to study the effects of mechanical dyssynchrony. The delayed contraction in the LV free wall with respect to the septum has a significant effect on LV function and coronary flow reserve.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00549.2020

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