Sex-specific responses to slow progressive pressure overload in a large animal model of HFpEF-Reference-Cited by-同舟云学术

Sex-specific responses to slow progressive pressure overload in a large animal model of HFpEF

Published:2022-10-01 Issue:4 Volume:323 Page:H797-H817
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Eaton Deborah M.¹²^ORCID,Berretta Remus M.¹²,Lynch Jacqueline E.²³⁴⁵⁶^ORCID,Travers Joshua G.⁷⁸^ORCID,Pfeiffer Ryan D.⁹^ORCID,Hulke Michelle L.⁹^ORCID,Zhao Huaqing¹⁰^ORCID,Hobby Alexander R. H.¹²,Schena Giana¹²,Johnson Jaslyn P.¹²,Wallner Markus¹²¹¹^ORCID,Lau Edward⁷⁸^ORCID,Lam Maggie P. Y.⁷⁸^ORCID,Woulfe Kathleen C.⁷⁸^ORCID,Tucker Nathan R.⁹¹²,McKinsey Timothy A.⁷⁸^ORCID,Wolfson Marla R.²³⁴⁵⁶^ORCID,Houser Steven R.¹²^ORCID

Affiliation:

1. Cardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania

2. Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania

3. Department of Physiology, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania

4. Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania

5. Department of Pediatrics, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania

6. Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania

7. Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado

8. Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, Colorado

9. Masonic Medical Research Institute, Utica, New York

10. Center for Biostatistics and Epidemiology, Department of Biomedical Education and Data Science, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania

11. Division of Cardiology, Medical University of Graz, Graz, Austria

12. Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Boston, Massachusetts

Abstract

We performed a comprehensive assessment to evaluate the effects of slow progressive pressure overload on cardiopulmonary function in a large animal model of heart failure with preserved ejection fraction (HFpEF) in males and females. Functional and structural assessments were performed at the organ, tissue, cellular, protein, and transcriptional levels. This is the first study to compare snRNAseq and ECM mass spectrometry of HFpEF myocardium from males and females. The results broaden our understanding of the pathophysiological response of both sexes to pressure overload. Both sexes developed a robust cardiopulmonary phenotype, but the phenotype was equal or a bit less robust in females.

Funder

Bayer Pharma, AG

Department of Defense-Department of Army, Army Research Laboratory

University of Colorado School of Medicine, Anschutz Medical Campus

University of Colorado School of Medicine, Anschutz Medical Campus, Consortium for Fibrosis Research and Translation

American Heart Association

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute on Aging

Publisher

American Physiological Society

Subject