Chronic perinatal hypoxia delays cardiac maturation in a mouse model for cyanotic congenital heart disease-Reference-Cited by-同舟云学术

Chronic perinatal hypoxia delays cardiac maturation in a mouse model for cyanotic congenital heart disease

Published:2021-05-01 Issue:5 Volume:320 Page:H1873-H1886
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Romanowicz Jennifer¹^ORCID,Guerrelli Devon¹²³,Dhari Zaenab⁴,Mulvany Colm²^ORCID,Reilly Marissa²,Swift Luther¹²,Vasandani Nimisha⁴,Ramadan Manelle¹²,Leatherbury Linda¹^ORCID,Ishibashi Nobuyuki¹²⁴⁵⁶,Posnack Nikki Gillum¹²⁵⁶^ORCID

Affiliation:

1. Children’s National Heart Institute, Children’s National Hospital, Washington, District of Columbia

2. Sheikh Zayed Institute for Pediatric Surgical Innovation, Children’s National Research Institute, Washington, District of Columbia

3. Department of Biomedical Engineering, George Washington University, Washington, District of Columbia

4. Center for Neuroscience Research, Children’s National Research Institute, Washington, District of Columbia

5. Department of Pediatrics, George Washington University, Washington, District of Columbia

6. Department of Pharmacology & Physiology, George Washington University, Washington, District of Columbia

Abstract

We utilized a new mouse model of chronic perinatal hypoxia to simulate the hypoxic myocardial conditions present in cyanotic congenital heart disease. Hypoxia caused numerous abnormalities in cardiomyocyte gene expression, the electrophysiologic substrate of the heart, and contractile function. Taken together, alterations observed in the neonatal period suggest delayed cardiac development immediately following hypoxia.

Funder

DOD | Office of the Secretary of Defense

HHS | National Institutes of Health

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00870.2020

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