Circulating lymphocyte trafficking to the bone marrow contributes to lymphopenia in myocardial infarction-Reference-Cited by-同舟云学术

Circulating lymphocyte trafficking to the bone marrow contributes to lymphopenia in myocardial infarction

Published:2022-04-01 Issue:4 Volume:322 Page:H622-H635
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Ma Yonggang¹^ORCID,Yang Xiaoyuan¹,Villalba Nuria¹,Chatterjee Victor¹,Reynolds Amanda¹,Spence Sam¹,Wu Mack H.²,Yuan Sarah Y.¹²

Affiliation:

1. Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida

2. Department of Surgery, University of South Florida Morsani College of Medicine, Tampa, Florida

Abstract

Lymphopenia, a reduction in blood lymphocyte count, is known to inversely correlate with the prognosis for patients with myocardial infarction (MI). However, the underlying mechanisms by which cardiac ischemia induces lymphopenia remain elusive. This study provides the first evidence that MI activates the hypothalamic-pituitary-adrenal (HPA) axis to increase glucocorticoid secretion, and elevated circulating glucocorticoids induce blood lymphocytes trafficking to the bone marrow, leading to lymphopenia.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of General Medical Sciences

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00003.2022

Reference61 articles.

1. Heart Disease and Stroke Statistics—2021 Update