Right ventricular metabolic adaptations to high-intensity interval and moderate-intensity continuous training in healthy middle-aged men

Author:

Heiskanen Marja A.1,Leskinen Tuija1,Heinonen Ilkka H. A.12,Löyttyniemi Eliisa3,Eskelinen Jari-Joonas1,Virtanen Kirsi1,Hannukainen Jarna C.1,Kalliokoski Kari K.1

Affiliation:

1. Turku PET Centre, University of Turku, Turku, Finland;

2. School of Sport Science, Exercise and Health, University Of Western Australia, Crawley, Western Australia, Australia; and

3. Department of Biostatistics, University of Turku, Turku, Finland

Abstract

Despite the recent studies on structural and functional adaptations of the right ventricle (RV) to exercise training, adaptations of its metabolism remain unknown. We investigated the effects of short-term, high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on RV glucose and fat metabolism. Twenty-eight untrained, healthy 40–55 yr-old-men were randomized into HIIT ( n = 14) and MICT ( n = 14) groups. Subjects performed six supervised cycle ergometer training sessions within 2 wk (HIIT session: 4–6 × 30 s all-out cycling/4-min recovery; MICT session: 40–60 min at 60% peak O2 uptake). Primary outcomes were insulin-stimulated RV glucose uptake (RVGU) and fasted state RV free fatty acid uptake (RVFFAU) measured by positron emission tomography. Secondary outcomes were changes in RV structure and function, determined by cardiac magnetic resonance. RVGU decreased after training (−22% HIIT, −12% MICT, P = 0.002 for training effect), but RVFFAU was not affected by the training ( P = 0.74). RV end-diastolic and end-systolic volumes, respectively, increased +5 and +7% for HIIT and +4 and +8% for MICT ( P = 0.002 and 0.005 for training effects, respectively), but ejection fraction mildly decreased (−2% HIIT, −4% MICT, P = 0.034 for training effect). RV mass and stroke volume remained unaltered. None of the observed changes differed between the training groups ( P > 0.12 for group × training interaction). Only 2 wk of physical training in previously sedentary subjects induce changes in RV glucose metabolism, volumes, and ejection fraction, which precede exercise-induced hypertrophy of RV. Listen to this article’s corresponding podcast at http://ajpheart.podbean.com/e/right-ventricular-metabolic-adaptations-to-exercise-training/ .

Funder

Suomen Akatemia (Academy of Finland)

Opetus- ja Kulttuuriministeriö (Ministry of Education and Culture, Finland)

Paavo Nurmi Foundation

Suomen Kulttuurirahasto (Finnish Cultural Foundation)

Emil Aaltosen Säätiö (Emil Aaltonen Foundation)

Novo Nordisk Foundation

European Foundation for the Study of Diabetes (EFSD)

Hospital District of Southwestern Finland

Orion Research Foundation

Yrjö Jahnsson Foundation

Turku University Foundation

Finnish Medical Foundation

Finnish Foundation for Cardiovascular Research

Finnish Diabetes Foundation

Paulo Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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