Deletion of DWORF does not affect cardiac function in aging and in PLN-R14del cardiomyopathy-Reference-Cited by-同舟云学术

Deletion of DWORF does not affect cardiac function in aging and in PLN-R14del cardiomyopathy

Published:2024-03-01 Issue:3 Volume:326 Page:H870-H876
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Stege Nienke M.¹^ORCID,Oliveira Nunes Teixeira Vivian¹^ORCID,Zijlstra Sietske N.¹^ORCID,Feringa Anna M.¹^ORCID,de Boer Rudolf A.¹²^ORCID,Silljé Herman H. W.¹^ORCID

Affiliation:

1. Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

2. Erasmus MC, Cardiovascular Institute, Thorax Center, Department of Cardiology, Rotterdam, The Netherlands

Abstract

Although DWORF overexpression significantly delayed heart failure development and strongly prolonged life span in PLN-R14del mice, the current study shows that deletion of DWORF does not accelerate or exacerbate PLN-R14del cardiomyopathy in mice harboring the pathogenic R14del allele. In addition, DWORF appears to be dispensable for cardiac function during aging. Changes in DWORF gene expression are therefore unlikely to contribute to the clinical heterogeneity observed in patients with PLN-R14del cardiomyopathy.

Funder

Fondation Leducq

Hartstichting

KNAW | Netherlands Heart Institute

Stichting PLN

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00741.2023

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