Global Reach 2018: sympathetic neural and hemodynamic responses to submaximal exercise in Andeans with and without chronic mountain sickness

Author:

Hansen Alexander B.1ORCID,Amin Sachin B.1ORCID,Hofstätter Florian1,Mugele Hendrik1ORCID,Simpson Lydia L.1,Gasho Christopher2,Dawkins Tony G.3ORCID,Tymko Michael M.45ORCID,Ainslie Philip N.5,Villafuerte Francisco C.6ORCID,Hearon Christopher M.78,Lawley Justin S.1ORCID,Moralez Gilbert7ORCID

Affiliation:

1. Division of Performance, Physiology and Prevention, Department of Sport Science, University of Innsbruck, Innsbruck, Austria

2. Division of Pulmonary and Critical Care, Department of Medicine, University of Loma Linda, Loma Linda, California

3. Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, United Kingdom

4. Physical Activity and Diabetes Laboratory, Faculty of Kinesiology and Recreation, University of Alberta, Edmonton, Alberta, Canada

5. Centre of Heart, Lung, and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada

6. Laboratorio de Fisiología Comparada/Fisiología del Transporte de Oxígeno Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru

7. Department of Applied Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas

8. Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Dallas, Dallas, Texas

Abstract

During submaximal exercise, convective oxygen transport is maintained in Andeans suffering from polycythemia. Light intensity exercise elicited similar cardiovascular and autonomic responses compared with healthy Andeans. However, during moderate-intensity exercise, we observed a blunted reduction in total peripheral resistance, which cannot be ascribed to an exaggerated increase in muscle sympathetic nerve activity, indicating possible contributions from other neural and/or nonneural mechanisms.

Funder

University of Innsbruck

Wilderness Medical Society

Canada Research Chair

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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