Impact of angiotensin II receptor antagonism on the sex-selective dysregulation of cardiovascular function induced by in utero dexamethasone exposure-Reference-Cited by-同舟云学术

Impact of angiotensin II receptor antagonism on the sex-selective dysregulation of cardiovascular function induced by in utero dexamethasone exposure

Published:2022-04-01 Issue:4 Volume:322 Page:H597-H606
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Madhavpeddi L.¹,Hammond B.¹,Carbone D. L.¹,Kang P.¹^ORCID,Handa R. J¹²,Hale T. M.¹^ORCID

Affiliation:

1. Department of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona

2. Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado

Abstract

Our findings reveal the involvement of angiotensin II on sex-selective cardiovascular function and autonomic changes in adult offspring exposed to dexamethasone during the last 4 days of gestation. We show that angiotensin II receptor blockade reverses the exaggerated pressor and heart rate response to acute restraint stress and the autonomic dysregulation observed in female, but not male, offspring exposed to dexamethasone in utero.

Funder

HHS | NIH | National Institute of Mental Health

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00587.2021

Reference52 articles.

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2. Epigenetics: New Concepts of Old Phenomena in Vascular Physiology

3. Sex-dependent programming effects of prenatal glucocorticoid treatment on the developing serotonin system and stress-related behaviors in adulthood

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