No influence on tumor growth by intramuscular injection of adipose-derived regenerative cells: safety evaluation of therapeutic angiogenesis with cell therapy-Reference-Cited by-同舟云学术

No influence on tumor growth by intramuscular injection of adipose-derived regenerative cells: safety evaluation of therapeutic angiogenesis with cell therapy

Published:2021-01-01 Issue:1 Volume:320 Page:H447-H457
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Suzuki Junya¹,Shimizu Yuuki¹,Tsuzuki Kazuhito¹,Pu Zhongyue¹,Narita Shingo¹,Yamaguchi Shukuro¹,Katagiri Takeshi¹,Iwata Etsuo¹,Masutomi Tomohiro¹,Fujikawa Yusuke¹,Shibata Rei²,Murohara Toyoaki¹

Affiliation:

1. Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

2. Department of Advanced Cardiovascular Therapeutics, Nagoya University Graduate School of Medicine, Nagoya, Japan

Abstract

In this study, we demonstrated that local injection of ADRCs can promote angiogenesis in response to tissue ischemia without promoting remote tumor growth in a mouse model. Our findings indicate that therapeutic angiogenesis to the ischemic hindlimb using ADRCs seems to be safe regarding remote tumor growth.

Funder

The Ministry of Education, Culture, Sports, Science and Technology of Japan

Chukyo longevity medical and promotion foundation awarded

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00564.2020

Reference43 articles.

1. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb

2. Arterial Gene Therapy for Therapeutic Angiogenesis in Patients With Peripheral Artery Disease