Cortical bone stem cells modify cardiac inflammation after myocardial infarction by inducing a novel macrophage phenotype-Reference-Cited by-同舟云学术

Cortical bone stem cells modify cardiac inflammation after myocardial infarction by inducing a novel macrophage phenotype

Published:2021-10-01 Issue:4 Volume:321 Page:H684-H701
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Hobby Alexander R. H.¹,Berretta Remus M.¹,Eaton Deborah M.¹,Kubo Hajime¹^ORCID,Feldsott Eric¹,Yang Yijun¹,Headrick Alaina L.²³,Koch Keith A.²³,Rubino Marcello²³,Kurian Justin⁴,Khan Mohsin¹⁴^ORCID,Tan Yinfei⁵,Mohsin Sadia¹⁶,Gallucci Stefania⁷^ORCID,McKinsey Timothy A.²³^ORCID,Houser Steven R.¹^ORCID

Affiliation:

1. Department of Physiology, Cardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania

2. Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado

3. Consortium for Fibrosis Research and Translation, University of Colorado Anschutz Medical Campus, Aurora, Colorado

4. Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania

5. Genomic Facility, Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania

6. Department of Pharmacology, Cardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania

7. Department of Microbiology & Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania

Abstract

Cortical bone stem cell (CBSC) therapy after myocardial infarction alters the inflammatory response to cardiac injury. We found that cortical bone stem cell therapy induces a unique macrophage phenotype in vitro and can modulate macrophage/fibroblast cross talk.

Funder

American Heart Association

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00304.2021

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