Extracellular vesicles enriched with miR-150 released by macrophages regulates the TP53-IGF-1 axis to alleviate myocardial infarction-Reference-Cited by-同舟云学术

Extracellular vesicles enriched with miR-150 released by macrophages regulates the TP53-IGF-1 axis to alleviate myocardial infarction

Published:2021-03-01 Issue:3 Volume:320 Page:H969-H979
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Zheng Suxia¹,Gong Maolei²,Chen Jing¹

Affiliation:

1. Department of Cardiology, Linyi People’s Hospital, Linyi, People’s Republic of China

2. Department of Critical Care Medicine, Aerospace Center Hospital (Aerospace Clinical Medical College of Peking University), Beijing, People’s Republic of China

Abstract

miR-150 is expressed at a low level in cardiac tissues after myocardial infarction. Macrophages-derived EVs transfer miR-150 to cardiomyocytes. miR-150 directly targets TP53. miR-150 elevation regulates TP53-IGF-1 axis to reduce cardiomyocyte apoptosis. EV-derived miR-150 could be a potential therapeutic target for myocardial infarction.

Funder

None

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00304.2020

Reference37 articles.

1. Extracellular Vesicles Secreted by Atherogenic Macrophages Transfer MicroRNA to Inhibit Cell Migration

2. Myocardial ischemia-reperfusion injury: a neglected therapeutic target

3. Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury