Resveratrol modulates the angiogenic response to exercise training in skeletal muscles of aged men

Author:

Gliemann Lasse1,Olesen Jesper2,Biensø Rasmus Sjørup2,Schmidt Jakob Friis1,Akerstrom Thorbjorn1,Nyberg Michael1,Lindqvist Anna1,Bangsbo Jens1,Hellsten Ylva1

Affiliation:

1. Integrative Physiology Group, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark; and

2. Centre of Inflammation and Metabolism, Department of Biology, University of Copenhagen, Copenhagen, Denmark

Abstract

In animal studies, the polyphenol resveratrol has been shown to influence several pathways of importance for angiogenesis in skeletal muscle. The aim of the present study was to examine the angiogenic effect of resveratrol supplementation with parallel exercise training in aged men. Forty-three healthy physically inactive aged men (65 ± 1 yr) were divided into 1) a training group that conducted 8 wk of intense exercise training where half of the subjects received a daily intake of either 250 mg trans-resveratrol ( n = 14) and the other half received placebo ( n = 13) and 2) a nontraining group that received either 250 mg trans-resveratrol ( n = 9) or placebo ( n = 7). The group that trained with placebo showed a ∼20% increase in the capillary-to-fiber ratio, an increase in muscle protein expression of VEGF, VEGF receptor-2, and tissue inhibitor of matrix metalloproteinase (TIMP-1) but unaltered thrombospodin-1 levels. Muscle interstitial VEGF and thrombospodin-1 protein levels were unchanged after the training period. The group that trained with resveratrol supplementation did not show an increase in the capillary-to-fiber ratio or an increase in muscle VEGF protein. Muscle TIMP-1 protein levels were lower in the training and resveratrol group than in the training and placebo group. Both training groups showed an increase in forkhead box O1 protein. In nontraining groups, TIMP-1 protein was lower in the resveratrol-treated group than the placebo-treated group after 8 wk. In conclusion, these data show that exercise training has a strong angiogenic effect, whereas resveratrol supplementation may limit basal and training-induced angiogenesis.

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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