The development of peripheral microvasculopathy with chronic metabolic disease in obese Zucker rats: a retrograde emergence?-Reference-Cited by-同舟云学术

The development of peripheral microvasculopathy with chronic metabolic disease in obese Zucker rats: a retrograde emergence?

Published:2022-09-01 Issue:3 Volume:323 Page:H475-H489
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Halvorson Brayden D.¹,Menon Nithin J.¹,Goldman Daniel¹,Frisbee Stephanie J.²,Goodwill Adam G.³^ORCID,Butcher Joshua T.⁴^ORCID,Stapleton Phoebe A.⁵,Brooks Steven D.⁶^ORCID,d’Audiffret Alexandre C.⁷,Wiseman Robert W.⁸⁹,Lombard Julian H.¹⁰,Brock Robert W.¹¹,Olfert I. Mark¹¹¹²^ORCID,Chantler Paul D.¹²^ORCID,Frisbee Jefferson C.¹^ORCID

Affiliation:

1. Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada

2. Department Pathology and Laboratory Medicine, University of Western Ontario, London, Ontario, Canada

3. Department of Integrative Medical Sciences, Northeastern Ohio Medical University, Rootstown, Ohio

4. Department of Physiological Sciences, Oklahoma State University, Stillwater, Oklahoma

5. Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey

6. Laboratory of Malaria and Vector Research, Physiology Unit, National Institute of Allergy and Infectious Diseases, Rockville, Maryland

7. Department of Cardiovascular and Thoracic Surgery, Rush Medical College, Chicago, Illinois

8. Department of Physiology, Michigan State University, East Lansing, Michigan

9. Department of Radiology, Michigan State University, East Lansing, Michigan

10. Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin

11. Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia

12. Division of Exercise Physiology, West Virginia University, Morgantown, West Virginia

Abstract

Working from an established database spanning multiple scales and times, we studied progression of peripheral microvascular dysfunction in chronic metabolic disease. The data implicate the postcapillary venular endothelium as the initiating site for vasculopathy. Indicators of dysfunction, spanning network structures, hemodynamics, vascular reactivity, and perfusion progress in an insidious retrograde manner to present as functional impairments to muscle blood flow and performance much later. The silent vasculopathy progression may provide insight into clinical treatment challenges.

Funder

American Heart Association

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Gouvernement du Canada | Canadian Institutes of Health Research

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute on Aging

HHS | NIH | Office of Extramural Research, National Institutes of Health

HHS | National Institutes of Health

Publisher

American Physiological Society

Subject