Low-dose morphine reduces tolerance to central hypovolemia in healthy adults without affecting muscle sympathetic outflow

Author:

Watso Joseph C.123ORCID,Belval Luke N.12ORCID,Cimino Frank A.1,Orth Bonnie D.1,Hendrix Joseph M.14ORCID,Huang Mu13ORCID,Johnson Elias1,Foster Josh12ORCID,Hinojosa-Laborde Carmen5ORCID,Crandall Craig G.123ORCID

Affiliation:

1. Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas

2. Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas

3. Department of Applied Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas

4. Department of Anesthesiology, University of Texas Southwestern Medical Center, Dallas, Texas

5. United States Army Institute of Surgical Research, Joint Base San Antonio Fort Sam Houston, Houston, Texas

Abstract

In this randomized, crossover, placebo-controlled trial, we found that tolerance to simulated hemorrhage was lower after low-dose morphine administration. Such reductions in hemorrhagic tolerance were observed without differences in MSNA burst frequency responses between morphine and placebo trials. These data, the first to be obtained in conscious humans, demonstrate that low-dose morphine reduces hemorrhagic tolerance. Thus, morphine is not an ideal analgesic for a hemorrhaging individual in the prehospital setting.

Funder

American Physiological Society

HHS | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Defense

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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