A pacing-controlled protocol for frequency-diastolic relations distinguishes diastolic dysfunction specific to a mouse HFpEF model-Reference-Cited by-同舟云学术

A pacing-controlled protocol for frequency-diastolic relations distinguishes diastolic dysfunction specific to a mouse HFpEF model

Published:2022-09-01 Issue:3 Volume:323 Page:H523-H527
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Numata Genri¹²^ORCID,Takimoto Eiki¹³^ORCID,Kariya Taro⁴,Adachi Yusuke¹,Tokiwa Hiroyuki¹,Toyoda Masayuki¹,Mafune Ryo⁵^ORCID,Saito Yoshihiro¹^ORCID,Nakamura Shun⁶^ORCID,Ueda Kazutaka¹,Ikeda Yuichi²,Komuro Issei¹

Affiliation:

1. Department of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan

2. Department of Advanced Translational Research and Medicine in Management of Pulmonary Hypertension, The University of Tokyo Hospital, Tokyo, Japan

3. Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland

4. Department of Anesthesiology and Pain Relief Center, The University of Tokyo, Tokyo, Japan

5. Department of Pediatrics, The University of Tokyo Hospital, Tokyo, Japan

6. Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Abstract

We developed a pacing-controlled PV loop protocol for the assessment of diastolic function at different heart rates in mice, which is a feasible and potent method for the characterization of diastolic dysfunction in a murine HFpEF model whose diastolic dysfunction might be difficult to be detected under resting conditions without pacing.

Funder

Fukuda Foundation for Medical Technology

MEXT | Japan Society for the Promotion of Science

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00241.2022

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1. Nitrosative stress drives heart failure with preserved ejection fraction

2. Exercise Stress Real-Time Cardiac Magnetic Resonance Imaging for Noninvasive Characterization of Heart Failure With Preserved Ejection Fraction