Predominant myosin superrelaxed state in canine myocardium with naturally occurring dilated cardiomyopathy-Reference-Cited by-同舟云学术

Predominant myosin superrelaxed state in canine myocardium with naturally occurring dilated cardiomyopathy

Published:2023-09-01 Issue:3 Volume:325 Page:H585-H591
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Ochala Julien¹^ORCID,Lewis Christopher T. A.¹^ORCID,Beck Thomas¹,Iwamoto Hiroyuki²,Hessel Anthony L.³⁴^ORCID,Campbell Kenneth S.⁵⁶^ORCID,Pyle W. Glen⁷⁸^ORCID

Affiliation:

1. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

2. SPring-8, Japan Synchrotron Radiation Research Institute, Hyogo, Japan

3. Institute of Physiology II, University of Muenster, Muenster, Germany

4. Accelerated Muscle Biotechnologies, Boston, Massachusetts, United States

5. Department of Physiology, University of Kentucky, Lexington, Kentucky, United States

6. Division of Cardiovascular Medicine, University of Kentucky, Lexington, Kentucky, United States

7. IMPART Investigator Team, Dalhousie Medicine, Saint John, New Brunswick, Canada

8. Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada

Abstract

The key finding of the present study is that, in left ventricles of dogs with a naturally occurring dilated cardiomyopathy, relaxed myosin molecules favor a nonsequestered superrelaxed state potentially impairing sarcomeric contractility. This alteration is rescuable by applying a small molecule activating myosin known as EMD-57033.

Funder

Carlsbergfondet

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00369.2023

Reference43 articles.

1. Prevalence of Dilated Cardiomyopathy in Doberman Pinschers in Various Age Groups

2. Effect of Pimobendan on Case Fatality Rate in Doberman Pinschers with Congestive Heart Failure Caused by Dilated Cardiomyopathy

3. Assessment of PDK4 and TTN gene variants in 48 Doberman Pinschers with dilated cardiomyopathy

4. A predictive model for canine dilated cardiomyopathy—a meta-analysis of Doberman Pinscher data

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