Age and sex dependency of thoracic aortopathy in a mouse model of Marfan syndrome-Reference-Cited by-同舟云学术

Age and sex dependency of thoracic aortopathy in a mouse model of Marfan syndrome

Published:2022-01-01 Issue:1 Volume:322 Page:H44-H56
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Gharraee Nazli¹^ORCID,Sun Yujian²,Swisher Joseph A.³,Lessner Susan M.¹⁴^ORCID

Affiliation:

1. Biomedical Engineering Program, University of South Carolina, Columbia, South Carolina

2. Physical Therapy Program, Brenau University, Gainesville, Georgia

3. Internal Medicine, Tulane University School of Medicine, New Orleans, Louisiana

4. Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, South Carolina

Abstract

Male Fbn-1C1041G/+ mice show more severe thoracic aortic changes compared with females, especially at 12 mo of age. Up to 6 mo of age, Sca-1+ smooth muscle progenitor cells are more abundant in the adventitia of both male and female Fbn-1 Het mice compared with wild types (WTs). Male and female Het mice show similar patterns of expression of Sca-1+ cells at early ages.

Funder

USC | Office of the Vice President for Research, University of South Carolina

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Biomedical Imaging and Bioengineering

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00255.2021

Reference52 articles.

1. Role of myofibroblasts in vascular remodelling: focus on restenosis and aneurysm