Atherogenic diet-diminished endothelial glycocalyx contributes to impaired vasomotor properties in rat-Reference-Cited by-同舟云学术

Atherogenic diet-diminished endothelial glycocalyx contributes to impaired vasomotor properties in rat

Published:2020-10-01 Issue:4 Volume:319 Page:H814-H823
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Kang Hongyan¹²^ORCID,Sun Anqiang¹²,Wu Qiuhong¹,Yang Jiali¹²,Zhang Weichen¹,Qu Yuxin¹,Gao Menghan¹,Deng Xiaoyan¹²

Affiliation:

1. Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, China

2. Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, China

Abstract

Twelve-week high-cholesterol (HC) diet reduces the thickness of the endothelial glycocalyx in Sprague-Dawley (SD) male rats, which is mainly attributed to a downregulation of heparan sulfate proteoglycan-related genes (syndecan-3, glypican-1, EXT1), not resulting from an enhanced shedding of sulfated glycosaminoglycans (sGAGs) into the plasma. HC-diminished glycocalyx may disturb its mechanotransduction of local shear stress, lower nitric oxide (NO) release, and impair vasomotor responses to norepinephrine (NE) and acetylcholine (ACh).

Funder

National Natural Science Foundation of China

The fundamental Research funds for central universities

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00039.2020

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