TMEM16A channel upregulation in arterial smooth muscle cells produces vasoconstriction during diabetes-Reference-Cited by-同舟云学术

TMEM16A channel upregulation in arterial smooth muscle cells produces vasoconstriction during diabetes

Published:2021-03-01 Issue:3 Volume:320 Page:H1089-H1101
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Leo M. Dennis¹²,Peixoto-Nieves Dieniffer¹,Yin Wen¹,Raghavan Somasundaram²^ORCID,Muralidharan Padmapriya¹,Mata-Daboin Alejandro¹,Jaggar Jonathan H.¹

Affiliation:

1. Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee

2. Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee

Abstract

We investigated the involvement of TMEM16A channels in vascular dysfunction during type 2 diabetes (T2D). TMEM16A message, protein, and currents were higher in smooth muscle cells of resistance-size arteries during T2D. Pressure stimulated greater vasoconstriction in the arteries of T2D mice that was abolished in the arteries of TMEM16A smKO mice. Akt2 protein and activity were both lower in T2D arteries, and Akt2 knockdown elevated TMEM16A protein. We propose that a decrease in Akt2 function stimulates TMEM16A expression in arterial smooth muscle cells, leading to vasoconstriction during T2D.

Funder

American Heart Association

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00690.2020

Reference59 articles.

1. Centers for Disease Control and Prevention. National Diabetes Statistics Report Atlanta, Atlanta, GA: Centers for Disease Control and Prevention, U.S. Dept of Health and Human Services, 2017.

2. Epidemiology of Diabetes and Diabetes-Related Complications

3. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I

4. Understanding the Type 2 Diabetes Mellitus and Cardiovascular Disease Risk Paradox

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