Influence of sex on global myocardial ischemia tolerance and mitochondrial function in circulatory death donor hearts-Reference-Cited by-同舟云学术

Influence of sex on global myocardial ischemia tolerance and mitochondrial function in circulatory death donor hearts

Published:2023-01-01 Issue:1 Volume:324 Page:H57-H66
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Chen Qun¹²^ORCID,Akande Oluwatoyin³,Lesnefsky Edward J.¹²⁴,Quader Mohammed²³⁵

Affiliation:

1. Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia

2. Pauley Heart Center, Virginia Commonwealth University Health System, Richmond, Virginia

3. Division of Cardiothoracic Surgery, Virginia Commonwealth University, Richmond, Virginia

4. Cardiology Section, Medical Service, McGuire Department of Veterans Affairs Medical Center, Richmond, Virginia

5. Cardiothoracic Surgery Section, Surgical Service, McGuire Department of Veterans Affairs Medical Center, Richmond, Virginia

Abstract

The current study shows cardiac injury is not increased in female DCD hearts following global ischemia-reperfusion compared with male DCD hearts. In addition, mitochondrial dysfunction with DCD ischemia-reperfusion is comparable in both sexes. Sex-specific immune responses and hormone receptor modulation may contribute to suboptimal outcomes in male HTx recipients with female donor hearts.

Funder

VA | Office of Academic Affiliations, Department of Veterans Affairs

Pauley Heart Center, VCU

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00478.2022

Reference41 articles.

1. Heart transplantation from donation after circulatory death donors: Present and future

2. Equally Interchangeable? How Sex and Gender Affect Transplantation

3. Survival Outcomes After Heart Transplantation

4. Gender differences in heart transplantation: Twenty‐five year trends in the nationwide Spanish heart transplant registry

5. Impact of gender on echocardiographic characteristics in heart transplant recipients

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