Simulated sleep apnea alters hydrogen sulfide regulation of blood flow and pressure-Reference-Cited by-同舟云学术

Simulated sleep apnea alters hydrogen sulfide regulation of blood flow and pressure

Published:2021-02-01 Issue:2 Volume:320 Page:H511-H519
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Barrera Adelaeda¹,Morales-Loredo Humberto¹,Garcia Joshua M.¹,Fregoso Gisel¹,Pace Carolyn E.¹,Mendiola Perenkita J.¹,Naik Jay S.¹^ORCID,Gonzalez Bosc Laura V.¹,Kanagy Nancy L.¹^ORCID

Affiliation:

1. Vascular Physiology Group, Department of Cell Biology and Physiology, School of Medicine, University of New Mexico, Albuquerque, New Mexico

Abstract

These results suggest that CSE’s protective role in the vasculature is impaired by simulated sleep apnea, which also upregulates CSE in the carotid body. Thus, this enzyme system can exert both pro- and antihypertensive effects and may contribute to elevated SNS outflow in sleep apnea.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Cancer Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00672.2019

Reference41 articles.

1. International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors

2. Dysregulation of cystathionine γ-lyase (CSE)/hydrogen sulfide pathway contributes to ox-LDL-induced inflammation in macrophage