The role of endothelial autocrine NRG1/ERBB4 signaling in cardiac remodeling-Reference-Cited by-同舟云学术

The role of endothelial autocrine NRG1/ERBB4 signaling in cardiac remodeling

Published:2020-08-01 Issue:2 Volume:319 Page:H443-H455
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Dugaucquier Lindsey¹^ORCID,Feyen Eline¹^ORCID,Mateiu Ligia²,Bruyns Tine Anne Marie¹,De Keulenaer Gilles W.¹³,Segers Vincent F. M.¹⁴^ORCID

Affiliation:

1. Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium

2. VIB Center for Molecular Neurology, University of Antwerp, Antwerp, Belgium

3. Department of Cardiology, Middelheim Hospital, Antwerp, Belgium

4. Department of Cardiology, University Hospital Antwerp, Edegem, Belgium

Abstract

The role of NRG1/ERBB signaling in endothelial cells is not completely understood. Our study contributes to the understanding of spatiotemporal heterogeneity of myocardial autocrine and paracrine responses following cardiac injury and shows a role of endothelial autocrine NRG1/ERBB4 signaling in the modulation of hypertrophic and fibrotic responses during early cardiac remodeling.

Funder

DocPro Ph.D. fellowship

Dehousse Ph.D. fellowship

IOF/SBO research grant

GOA grant

Senior Clinical Investigator fellowship

Scientific Research Flanders

ERA.Net RUS Plus

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology