Sex-based differences in metabolic protection by the ANP genetic variant rs5068 in the general population-Reference-Cited by-同舟云学术

Sex-based differences in metabolic protection by the ANP genetic variant rs5068 in the general population

Published:2023-09-01 Issue:3 Volume:325 Page:H545-H552
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Ichiki Tomoko¹²,Cannone Valentina¹³^ORCID,Scott Christopher G.⁴^ORCID,Iyer Seethalakshmi R.¹,Sangaralingham S. Jeson¹,Bailey Kent R.⁴,Goetze Jens P.⁵,Tsuji Yoshihisa²,Rodeheffer Richard J.¹,Burnett John C.¹^ORCID

Affiliation:

1. Cardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States

2. Department of Community and General Medicine, School of Medicine, Sapporo Medical University, Sapporo, Japan

3. Department of Medicine and Surgery, University of Parma, Parma, Italy

4. Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States

5. Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

Abstract

Males are characterized by lower ANP and BNP with greater prevalence of cardiometabolic disease. The ANP genetic variant rs5068 was associated with less metabolic dysfunction in males, whereas no metabolic profile was related to the BNP genetic variant rs198389 in the general population. ANP may play a more biological role in metabolic homeostasis compared with BNP in the general population with greater physiological metabolic actions in males compared with females.

Funder

Mayo Foundation

American Heart Association

HHS | NIH | NHLBI | NHLBI Division of Intramural Research

HHS | NIH | National Institute on Aging

Japan Society for the Promotion of Science London

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00321.2023