Potential mechanism of left ventricular spherical remodeling: association of mitral valve complex-myocardium longitudinal tissue remodeling mismatch-Reference-Cited by-同舟云学术

Potential mechanism of left ventricular spherical remodeling: association of mitral valve complex-myocardium longitudinal tissue remodeling mismatch

Published:2020-09-01 Issue:3 Volume:319 Page:H694-H704
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Nagata Yasufumi¹²^ORCID,Iwataki Mai¹,Nabeshima Yosuke¹^ORCID,Hei Soshi¹^ORCID,Onoue Takeshi¹,Hayashi Atsushi¹,Otani Kyoko³,Tsuda Yuki¹,Araki Masaru¹^ORCID,Kim Dae-Hee⁴,Song Jae-Kwan⁴,Hayashida Akihiro⁵^ORCID,Toki Misako⁶,Yuasa Toshinori⁷,Mizukami Naoko⁸,Nishimura Yosuke⁹,Levine Robert A.²,Otsuji Yutaka¹

Affiliation:

1. Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan

2. Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts

3. Department of Laboratory and Transfusion Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan

4. Department of Echocardiography, Asan Medical Center, Seoul, Korea

5. Department of Cardiology, the Sakakibara Heart Institution of Okayama, Okayama, Japan

6. Department of Clinical Laboratory, the Sakakibara Heart Institution of Okayama, Okayama, Japan

7. Department of Cardiovascular Medicine and Hypertension, Graduate School of Medicine and Dental Science, Kagoshima University, Kagoshima, Japan

8. Department of Clinical Laboratory, Graduate School of Medicine and Dental Science, Kagoshima University, Kagoshima, Japan

9. Department of Cardiovascular Surgery, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan

Abstract

Left ventricular (LV) spherical remodeling is associated with poor prognosis and less-effective cardiac performance, which commonly develops in dilated cardiomyopathy. However, its mechanism remains unclear. We hypothesized and subsequently clarified that less mitral valve complex (MVC) tissue longitudinal elongation relative to whole LV myocardial tissue longitudinal elongation is related to disproportionately less LV base longitudinal versus transverse myocardial tissue elongation, constituting spherical remodeling. This study suggests modification of MVC tissue elongation could be potential therapeutic targets.

Funder

the Japan Society of the Promotion of Science

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00279.2020

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