Microvascular dysfunction and neurovascular uncoupling are exacerbated in peripheral artery disease, increasing the risk of cognitive decline in older adults

Author:

Owens Cameron D.1ORCID,Mukli Peter123,Csipo Tamas13ORCID,Lipecz Agnes13,Silva-Palacios Federico4,Dasari Tarun W.5ORCID,Tarantini Stefano1367,Gardner Andrew W.8,Montgomery Polly S.8,Waldstein Shari R.910,Kellawan J. Mikhail11ORCID,Nyul-Toth Adam1312,Balasubramanian Priya16ORCID,Sotonyi Peter13,Csiszar Anna1614,Ungvari Zoltan1367,Yabluchanskiy Andriy167ORCID

Affiliation:

1. Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

2. International Training Program in Geroscience, Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary

3. International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary

4. Vascular Medicine Program, Cardiovascular Section, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

5. Cardiovascular Section, Department of Internal Medicine, Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

6. The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

7. Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

8. Department of Physical Medicine and Rehabilitation, Penn State College of Medicine, Hershey, Pennsylvania

9. Department of Psychology, University of Maryland, Baltimore County, Baltimore, Maryland

10. Geriatric Research, Education, and Clinical Center, Baltimore Veterans Affairs Medical Center, Baltimore, Maryland

11. Department of Health and Exercise Science, University of Oklahoma, Norman, Oklahoma

12. International Training Program in Geroscience, Institute of Biophysics, Biological Research Centre, Eötvös Loránd Research Network, Szeged, Hungary

13. Department of Vascular and Endovascular Surgery, Heart and Vascular Center, Semmelweis University, Budapest, Hungary

14. International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Translational Medicine, Semmelweis University, Budapest, Hungary

Abstract

Peripheral artery disease (PAD) was associated with significantly decreased cognitive performance, impaired neurovascular coupling (NVC) responses in the prefrontal cortex (PFC), left and right dorsolateral prefrontal cortices (LDLPFC and RDLPFC), and impaired peripheral microvascular endothelial function. A positive correlation between microvascular endothelial function, NVC responses, and cognitive performance may suggest that PAD-related cognitive decrement is mechanistically linked, at least in part, to generalized microvascular endothelial dysfunction and subsequent impairment of NVC responses.

Funder

American Heart Association

Reynolds Foundation

Ministry for Innovation and Technology of Hungary

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | National Institute of Neurological Disorders and Stroke

HHS | NIH | National Institute on Aging

Presbyterian Health Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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