Early- to mid-gestational testosterone excess leads to adverse cardiac outcomes in postpartum sheep-Reference-Cited by-同舟云学术

Early- to mid-gestational testosterone excess leads to adverse cardiac outcomes in postpartum sheep

Published:2024-08-01 Issue:2 Volume:327 Page:H315-H330
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Alkhatib Bashar¹^ORCID,Ciarelli Joseph²,Ghnenis Adel²,Pallas Brooke³,Olivier Nicholas⁴,Padmanabhan Vasantha²^ORCID,Vyas Arpita Kalla¹^ORCID

Affiliation:

1. Department of Pediatrics, Washington University, St Louis, Missouri, United States

2. Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, United States

3. Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan, United States

4. Department of Veterinary Medicine, Michigan State University, Lansing, Michigan, United States

Abstract

Using a sheep model of human translational relevance, this study provides evidence that excess gestational testosterone exposure such as that seen in hyperandrogenic disorders adversely impacts postpartum maternal hearts.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00763.2023

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