Highs and lows of sympathetic neurocardiovascular transduction: influence of altitude acclimatization and adaptation-Reference-Cited by-同舟云学术

Highs and lows of sympathetic neurocardiovascular transduction: influence of altitude acclimatization and adaptation

Published:2020-12-01 Issue:6 Volume:319 Page:H1240-H1252
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Berthelsen Lindsey F¹,Fraser Graham M.²^ORCID,Simpson Lydia L.³,Vanden Berg Emily R.¹,Busch Stephen A.¹,Steele Andrew R.¹^ORCID,Meah Victoria L.¹^ORCID,Lawley Justin S.⁴^ORCID,Figueroa-Mujíca Romulo J.⁵,Vizcardo-Galindo Gustavo⁵^ORCID,Villafuerte Francisco⁵^ORCID,Gasho Chris⁶,Willie Christopher K.⁷,Tymko Michael M.¹⁷,Ainslie Philip N.⁷,Stembridge Mike⁸^ORCID,Moore Jonathan P.³^ORCID,Steinback Craig D.¹

Affiliation:

1. Neurovascular Health Laboratory, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Alberta, Canada

2. Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland and Labrador, Canada

3. School of Sport, Health and Exercise Science, Bangor University, Bangor, United Kingdom

4. Department of Sport Science, Division of Physiology, University of Innsbruck, Innsbruck, Austria

5. Laboratorio de Fisiologia Comparada, Departamento de Ciencias Biologicas y Fisiologicas, Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru

6. Division of Pulmonary and Critical Care, School of Medicine, Loma Linda University, Loma Linda, California

7. Centre for Heart, Lung, and Vascular Health, University of British Columbia Okanagan, Kelowna, Canada

8. Cardiff Centre for Exercise and Health, Cardiff School of Sport and Health, Cardiff Metropolitan University, Cardiff, United Kingdom

Abstract

This study has identified that sympathetically mediated blood pressure regulation is reduced following ascent to high altitude. Additionally, we show that high-altitude Andean natives have reduced blood pressure responsiveness to sympathetic nervous activity (SNA) outflow compared with Nepalese Sherpa. However, basal sympathetic activity is inversely related to the magnitude of SNA-mediated fluctuations in blood pressure regardless of population or condition. These data set a foundation to explore more precise mechanisms of blood pressure control under conditions of persistent sympathetic activation and hypoxia.

Funder

Canadian Research Chair in Cerebrovascular Physiology

Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00364.2020

Reference42 articles.

1. Clearing the (high) air

2. Andean, Tibetan, and Ethiopian patterns of adaptation to high-altitude hypoxia