Experimental high thoracic spinal cord injury impairs the cardiac and cerebrovascular response to orthostatic challenge in rats

Author:

Hayes Brian D.12,Fossey Mary Pauline Mona13ORCID,Poormasjedi-Meibod Malihe-Sadat1,Erskine Erin14,Soriano Jan Elaine5ORCID,Scott Berkeley5,Rosentreter Ryan5,Granville David J.16ORCID,Phillips Aaron A.5,West Christopher R.14ORCID

Affiliation:

1. International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia, Canada

2. School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada

3. Experimental Medicine, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

4. Department of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

5. Departments of Physiology and Pharmacology, Cardiac Sciences, Clinical Neurosciences, Libin Cardiovascular Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

6. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

Abstract

This is the first use of LBNP to interrogate the cardiac and cerebrovascular responses to simulated OH in a preclinical study of SCI. Here, we demonstrate the utility of our simulated OH model and use it to demonstrate that SCI impairs the cardiac response to simulated OH and disrupts dynamic cerebrovascular autoregulation.

Funder

Canada Foundation of Innovation

British Columbia (BC) Development Fund

Heart and Stroke Foundation of Canada

Michael Smith Foundation for Health Research

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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