A novel system for mapping regional electrical properties and characterizing arrhythmia in isolated intact rat atria-Reference-Cited by-同舟云学术

A novel system for mapping regional electrical properties and characterizing arrhythmia in isolated intact rat atria

Published:2021-08-01 Issue:2 Volume:321 Page:H412-H421
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Ramlugun Girish S.¹^ORCID,Sands Gregory B.¹,Zhao Jichao¹^ORCID,LeGrice Ian J.¹²,Smaill Bruce H.¹²

Affiliation:

1. Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand

2. Department of Physiology, University of Auckland, Auckland, New Zealand

Abstract

Despite wide-ranging optical mapping studies, detailed information on regional atrial electrical properties in small animal models of heart disease and how these contribute to reentrant arrhythmia remains limited. We have developed a novel experimental platform that enables both to be achieved in a geometrically intact isolated rat bi-atrial preparation.

Funder

Manatu Hauora | Health Research Council of New Zealand

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00185.2021

Reference34 articles.

1. Murine Electrophysiological Models of Cardiac Arrhythmogenesis

2. Atrial Arrhythmia in Ageing Spontaneously Hypertensive Rats: Unraveling the Substrate in Hypertension and Ageing

3. Unprovoked atrial tachyarrhythmias in aging spontaneously hypertensive rats: the role of the autonomic nervous system

4. Increased Vulnerability to Atrial Fibrillation in Transgenic Mice With Selective Atrial Fibrosis Caused by Overexpression of TGF-β1

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