Sexual dimorphism in testosterone programming of cardiomyocyte development in sheep-Reference-Cited by-同舟云学术

Sexual dimorphism in testosterone programming of cardiomyocyte development in sheep

Published:2022-04-01 Issue:4 Volume:322 Page:H607-H621
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Ghnenis Adel¹^ORCID,Padmanabhan Vasantha¹^ORCID,Vyas Arpita²^ORCID

Affiliation:

1. Department of Pediatrics, University of Michigan, Ann Arbor, Michigan

2. College of Human Medicine, California Northstate University, Elk Grove, California

Abstract

The present study demonstrates sex-specific effects of gestational T excess between days 30 and 90 of gestation on the cardiac phenotype. Furthermore, the sex-specific programming is likely secondary to perturbation in both estrogen and insulin signaling pathways collectively. These findings are supportive of the role of androgen excess to serve as early biomarkers of CVD and could be critical in identifying therapeutic targets for LV hypertrophy and predict long-term CVD.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00691.2021

Reference88 articles.

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3. Sex-Specific Perturbation of Systemic Lipidomic Profile in Newborn Lambs Impacted by Prenatal Testosterone Excess;Endocrinology;2023-12-07

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