The peroxisomal enzyme, FAR1, is induced during ER stress in an ATF6-dependent manner in cardiac myocytes-Reference-Cited by-同舟云学术

The peroxisomal enzyme, FAR1, is induced during ER stress in an ATF6-dependent manner in cardiac myocytes

Published:2021-05-01 Issue:5 Volume:320 Page:H1813-H1821
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Marsh Kayleigh G.¹,Arrieta Adrian¹²^ORCID,Thuerauf Donna J.¹,Blackwood Erik A.¹³^ORCID,MacDonnell Lauren¹³,Glembotski Christopher C.¹³

Affiliation:

1. San Diego State University Heart Institute and Department of Biology, San Diego State University, San Diego, California

2. Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine at University of California, Los Angeles, California

3. Department of Internal Medicine and the Center for Translational Cardiovascular Research, University of Arizona, Phoenix, Arizona

Abstract

The peroxisomal enzyme, FAR1, was shown to be an ER stress- and ATF6-inducible protein that localizes to peroxisomes in cardiac myocytes. FAR1 decreases myocyte viability during oxidative stress.

Funder

HHS | NIH | Office of Extramural Research, National Institutes of Health

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00999.2020

Reference17 articles.

1. ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb

2. ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart

3. Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1