Desmin is essential for the structure and function of the sinoatrial node: implications for increased arrhythmogenesis-Reference-Cited by-同舟云学术

Desmin is essential for the structure and function of the sinoatrial node: implications for increased arrhythmogenesis

Published:2020-09-01 Issue:3 Volume:319 Page:H557-H570
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Mavroidis Manolis¹^ORCID,Athanasiadis Nikolaos C.²,Rigas Pavlos¹,Kostavasili Ioanna¹^ORCID,Kloukina Ismini¹,Te Rijdt Wouter P.³⁴,Kavantzas Nikolaos⁵,Chaniotis Dimitris²,van Tintelen J. Peter⁶^ORCID,Skaliora Irini¹^ORCID,Davos Constantinos H.²

Affiliation:

1. Center of Basic Research, Biomedical Research Foundation, Academy of Athens, Athens, Greece

2. Center of Clinical Research and Experimental Surgery, Biomedical Research Foundation, Academy of Athens, Athens, Greece

3. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

4. Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

5. First Department of Pathology, National and Kapodistrian University of Athens, Athens, Greece

6. Department of Genetics, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands

Abstract

The sinoatrial node exhibits high amounts of desmin and desmoplakin in structures we call “lateral intercalated disks,” connecting side-by-side adjacent cardiomyocytes. These structures are diminished in desmin-deficient mouse models. Misregulation of T-type Ca2+ current and hyperpolarization-activated cyclic nucleotide-gated K+ channel 1 was proved along with prolonged interatrial conduction and cardiac autonomic nervous system dysfunction.

Funder

Hellenic Society of Cardiology

General Secretariat of Research and Techology, Greece

CVON PREDICT, Dutch Heart Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00594.2019

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1. HTSeq--a Python framework to work with high-throughput sequencing data