Regional beat-to-beat variability of repolarization increases during ischemia and predicts imminent arrhythmias in a pig model of myocardial infarction

Author:

Amoni Matthew12,Ingelaere Sebastian12ORCID,Moeyersons Jonathan3,Wets Dries1,Tanushi Aldo1,Van Huffel Sabine3,Varon Carolina34ORCID,Sipido Karin1,Claus Piet5ORCID,Willems Rik12ORCID

Affiliation:

1. Experimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium

2. Department of Cardiology, University Hospitals, Leuven, Belgium

3. Department of Electrical Engineering, STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium

4. Microgravity Research Center, Université Libre de Bruxelles, Brussels, Belgium

5. Cardiovascular Imaging and Dynamics, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium

Abstract

The key finding of this study is that BVR increases during AMI and surges before ventricular arrhythmia onset. This suggests that monitoring BVR may be useful for monitoring the risk of VF during and after AMI in the coronary care unit settings. Beyond this, monitoring BVR may have value in cardiac implantable devices or wearables.

Funder

European Space Agency

Fonds Wetenschappelijk Onderzoek

Onderzoeksraad, KU Leuven

Vlaamse regering

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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