Th17 cell-linked mechanisms mediate vascular dysfunction induced by testosterone in a mouse model of gender-affirming hormone therapy-Reference-Cited by-同舟云学术

Th17 cell-linked mechanisms mediate vascular dysfunction induced by testosterone in a mouse model of gender-affirming hormone therapy

Published:2022-08-01 Issue:2 Volume:323 Page:H322-H335
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Santos Jeimison D.¹^ORCID,Oliveira-Neto José T.¹^ORCID,Barros Paula R.¹,Damasceno Luis E. A.¹^ORCID,Lautherbach Natalia²^ORCID,Assis Ana P.²^ORCID,Silva Carlos A. A.³,Sorgi Carlos A.⁴,Faccioli Lucia H.⁵,Kettelhut Isis C.²,Salgado Hélio C.³^ORCID,Carneiro Fernando S.¹,Alves-Filho José C.¹,Tostes Rita C.¹^ORCID

Affiliation:

1. Department of Pharmacology, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil

2. Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil

3. Department of Physiology, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil

4. Department of Chemistry, Faculty of Philosophy, Sciences and Letters at Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil

5. Department of Clinical Analyses, Toxicology and Food Science, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil

Abstract

Sex hormone-induced cardiovascular events are important undesirable effects in transgender people under GAHT. Studies addressing the cardiovascular impact of GAHT will certainly contribute to improve healthcare services offered to this population. Our study showing that vascular dysfunction, via Th17 cell-related mechanisms, precedes increased blood pressure induced by testosterone in a GAHT mouse model, reveals potential mechanisms involved in GAHT-related cardiovascular events and may provide new markers/targets for clinical practices in transmasculine people.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00182.2022

Reference51 articles.

1. Size and Distribution of Transgender and Gender Nonconforming Populations