Cardioprotective response and senescence in aged sEH null female mice exposed to LPS-Reference-Cited by-同舟云学术

Cardioprotective response and senescence in aged sEH null female mice exposed to LPS

Published:2024-06-01 Issue:6 Volume:326 Page:H1366-H1385
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Yousef Ala¹,Sosnowski Deanna K.¹^ORCID,Fang Liye¹²^ORCID,Legaspi Renald James³,Korodimas Jacob¹²,Lee Andy¹⁴,Magor Katharine E.³,Seubert John M.¹²^ORCID

Affiliation:

1. Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada

2. Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

3. Department of Biological Sciences, Faculty of Science, University of Alberta, Edmonton, Alberta, Canada

4. Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

Abstract

Soluble epoxide hydrolase (sEH) is an essential enzyme for converting epoxy fatty acids to their less bioactive diols. Our study suggests deletion or inhibition of sEH impacts the aging process in the hearts of female mice resulting in cardioprotection. Data indicate targeting sEH limits inflammation, preserves mitochondria, and alters cellular senescence in the aged female heart.

Funder

Nemat Al-Tawfiq for Training and Rehabilitation

KEM

DOST University of Alberta S&T

Canadian Government | Canadian Institutes of Health Research

Canadian Government | Natural Sciences and Engineering Research Council of Canada

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00706.2023

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