Exercise-mitigated sex-based differences in aging: from genetic alterations to heart performance-Reference-Cited by-同舟云学术

Exercise-mitigated sex-based differences in aging: from genetic alterations to heart performance

Published:2021-02-01 Issue:2 Volume:320 Page:H854-H866
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Börzsei Denise¹,Priksz Dániel²,Szabó Renáta¹³,Bombicz Mariann²,Karácsonyi Zoltán⁴,Puskás László G.⁵⁶,Fehér Liliána Z.⁵,Radák Zsolt⁷,Kupai Krisztina¹,Berkó Anikó Magyariné¹^ORCID,Varga Csaba¹,Juhász Béla²,Pósa Anikó¹³

Affiliation:

1. Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary

2. Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

3. Department of Physiology, Anatomy and Neuroscience, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary

4. Department of Orthopedics, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

5. Avidin Limited, Szeged, Hungary

6. Laboratory of Functional Genomics, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary

7. Research Institute of Sport Science, University of Physical Education, Budapest, Hungary

Abstract

Voluntary exercise has proved to be an effective therapeutic tool to improve cardiac function in aged rats with clearly visible sex differences. Long-term exercise is associated with decreased Ogn and Comt expression and enhanced presence of Pcp4 and Esm1 genes. Sex-dependent changes were also observed in the expression of the cardiovascular key proteins. Fundamental alterations in gene and protein expression may contribute to the improvement of cardiac performance.

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00643.2020

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