Abnormally low sensorimotor α band nonlinearity serves as an effective EEG biomarker of Parkinson’s disease-Reference-Cited by-同舟云学术

Abnormally low sensorimotor α band nonlinearity serves as an effective EEG biomarker of Parkinson’s disease

Published:2024-02-01 Issue:2 Volume:131 Page:435-445
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Özkurt Tolga Esat¹^ORCID

Affiliation:

1. Department of Health Informatics, Graduate School of Informatics, Middle East Technical University (METU), Ankara, Turkey

Abstract

This study suggests a nonlinearity measure that differentiates Parkinson’s disease (PD) dopamine OFF-state scalp EEG data from those of dopamine ON-state patients and healthy subjects. Unlike typical PD cortical biomarkers based on β band activity, this metric shows elevation upon dopaminergic medication in the α band. We provide evidence supporting its potential as an early-stage promising PD biomarker that can be estimated from noninvasive EEG recordings with low resolution and SNR.

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00272.2023

Reference61 articles.

1. Normal and pathological oscillatory communication in the brain

2. A systematic review of local field potential physiomarkers in Parkinson’s disease: from clinical correlations to adaptive deep brain stimulation algorithms

3. Scales for rating motor impairment in Parkinson's disease: studies of reliability and convergent validity.

4. Oscillatory nature of human basal ganglia activity: Relationship to the pathophysiology of Parkinson's disease

5. Distinct oscillatory STN-cortical loops revealed by simultaneous MEG and local field potential recordings in patients with Parkinson's disease