Andexanet alfa (ONDEXXYA<sup>®</sup> for Intravenous Injection 200 mg), a reversal agent for direct factor Xa inhibitors: pharmacological characteristics and clinical evidence
Author:
Affiliation:
1. Cardiovascular, Renal, and Metabolism, Medical Affairs, AstraZeneca K.K.
2. Data Science & Innovation Division, Research and Development, AstraZeneca K.K.
Publisher
Japanese Pharmacological Society
Subject
Pharmacology
Link
https://www.jstage.jst.go.jp/article/fpj/158/1/158_22107/_pdf
Reference23 articles.
1. 1) Connolly SJ, et al. N Engl J Med. 2009;361:1139-1151.
2. 2) Connolly SJ, et al. N Engl J Med. 2010;363:1875-1876.
3. 3) Granger CB, et al. N Engl J Med. 2011;365:981-992.
4. 4) Patel MR, et al. N Engl J Med. 2011;365:883-891.
5. 5) Giugliano RP, et al. N Engl J Med. 2013;369:2093-2104.
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2. Acute Aortic Dissection Managed with Nafamostat for Heparin Resistance in the Presence of DOAC Reversal Agent: a Case Report;Japanese Journal of Cardiovascular Surgery;2024-05-15
3. Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity: Prespecified Subgroup Analysis of the ANNEXA-4 Study in Japan;Journal of Atherosclerosis and Thrombosis;2023
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